The cleanest bioavailable B-complex.

This exceptional full spectrum B-complex has shown beneficial for:

   – Energy
   – Hormone balance
   – Cognitive function
   – Thyroid
   – Mood stability
   – Immune system
   – Nervous system
   – Detoxification
   – Vegans    
   – Peripheral Neuropathy
   – Skin

Organic, vegan, non-GMO, gluten-free, GMP. Made in the USA.

33 vegan capsules per glass jar. 

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
If you are pregnant or nursing, please consult a healthcare practitioner.

– Vegan
– Gluten-free
– Non-GMO
– Third party tested
– NSF GMP certified
– Organic

Made in USA

Contains NO soy, corn, dairy, silica, silicon dioxide, amorphous silica, magnesium stearate, stearic acid, magnesium sulfate, carrageenan, pectin, ethylene oxide, preservative, gelling agents, or any known harmful fillers.

Passed Lab Tests: purity, gluten, pesticides, heavy metals, micro bacterial

Storage: Store in a cool, dry place away from direct sunlight and moisture.  

For optimal results: Take 1 capsule daily with room temperature water in the morning either on an empty stomach or after your first meal.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant or nursing, please consult a healthcare practitioner.

Thiamin (B1) as Thiamine Pyrophosphate 3mg
Riboflavin (B2) as Riboflavin 5'-Phosphate 11 mg
Niacin (B3) as Niacinamide 33 mg
Pantothenic Acid (B5) as Calcium Pantothenate 6 mg
Pyridoxine (B6) as Pyridoxal 5'-Phosphate 11 mg
Folate (B9) as L-5-Methyltetrahydrofolate 666 mcg
Cobalamin (B12) as Methylcobalamin 1111 mcg
Organic shiitake mushroom 411mg
Other ingredients: HPMC 100% vegan hypromellose capsule, organic unrefined virgin cold-pressed hemp seed oil

B1 known as Thiamine  /  Active Form: Thiamine Pyrophosphate 

Catabolizes carbohydrates and amino acids

An essential micronutrient that cannot be made in the body and every cell in the body needs thiamine to synthesize A TP (adenosine triphosphate), a source of energy for the cells

Deficiency may cause muscle weakness, tingling/numbness in feet/hands, swollen feet, neurological abnormalities (confusion, memory loss), congestive heart failure

Ingestion of excessive simple carbohydrates automatically increases the need for this vitamin

B2 known as Riboflavin  /  Active Form: Riboflavin 5'-Phosphate 

Essential for metabolism of carbohydrates, proteins, and fats into glucose for energy

Activates MTHFR enzyme so folate (B9) can convert homocysteine to methionine. People can eat plenty of dark leafy greens for folate or take high dose MTHF but there needs to be enough riboflavin (B2) to activate MTHFR.

Regulates homocysteine, an amino acid involved in blood clot, heart attack, and stroke

Functions as an antioxidant for the proper functioning of immune system, healthy skin, and hair 

May help prevent cataracts by protection against free radicals in eyes

Contributes to the reduced risk of some forms of cancer in humans

B3 known as Niacin  /  Active Form: Niacinamide 

May significantly reduce triglycerides and LDL while raising HDL

An essential micronutrient that cannot be made in the body

Helps convert food into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects

Deficiency may cause sun-sensitive dermatitis involving hyperpigmentation and psychiatric symptoms such as poor concentration, anxiety, depression, and restlessness

Key component for treatment and reversal of fatty liver disease

B5 known as Pantothenic Acid  /  Active Form: Calcium Pantothenate

Synthesizes CoA (coenzyme A), a primary input in the Krebs cycle, that is essential for fatty acid metabolism

Supports adrenal glands thereby regulating stress hormone cortisol and improve stress resiliency

Severe deficiency may cause numbness and burning of hands and feet, muscle cramps, fatigue, disturbed sleep

Critical for manufacturing red blood cells

The large intestines produce B5 but not enough to meet dietary needs

B6 known as Pyridoxine  /  Active Form: Pyridoxal 5'-Phosphate 

Keeps the liver functioning optimally by promoting the proper flow of fat and bile to and from the liver

An essential micronutrient the body cannot produce that is responsible for nearly 200 chemical processes in the body

Synthesizes hormones serotonin, dopamine, norepinephrine and neurotransmitter GABA

Promotes better circulation, better mood, stronger immune system, reduce risk of cancer/slow tumor growth 

A master cofactor for metabolizing amino acids, the building blocks of all proteins and hormones, one of which is glycine. Glycine along with cysteine and glutamic acid synthesize glutathione, a master antioxidant

Helps produce lymphocytes, a type of white blood cell, that attacks invading bacteria, viruses, and toxins 

Supports COMT (Catechol-O-methyltransferase) that degrades excess estrogen to promote hormone balance

B9 known as Folate  /  Active Form: L-5-Methyltetrahydrofolate 

An essential micronutrient the body does not make that is required for red blood cell formation 

Crucial during period of frequent cell division and growth such as infancy and early pregnancy to reduce risk of birth defects of the brain and spine

Modulates red blood cell size in order to fit into smaller capillaries to transport oxygen from lungs to body tissues. It’s used to treat anemia in which RBCs become abnormally large.

Required for DNA, RNA, and protein methylation

Helps reduce risk of cognitive impairment, dementia, and Alzheimer’s by lowering homocysteine

Supports COMT (Catechol-O-methyltransferase) that degrades excess estrogen to promote hormone balance

B12 known as Cobalamin  /  Active Form: Methylcobalamin 

An essential micronutrient the body cannot produce and is vital for synthesizing myelin, a sheath that forms around nerves, including in the brain and spinal cord, that allows electrical impulses to transmit efficiently. Damage to myelin causes walking and balance problems, vision problems, and pain.

Deficiency can cause severe damage to the brain and nervous system

Modulates red blood cell size in order to fit into smaller capillaries to transport oxygen from lungs to body tissues. It’s used to treat anemia in which RBCs become abnormally large.

Required for DNA, RNA, and protein methylation

Required to produce red blood cells

Supports COMT (Catechol-O-methyltransferase) that degrades excess estrogen to promote hormone balance

Organic shiitake mushroom 

Significant source of plant-based choline (known as B4)

The brain and nervous system needs choline to regulate memory, mood, and muscle control

Choline is an essential micronutrient that is a methyl donor which influences DNA methylation

Choline is required to form membranes around the body’s cells that is critical for transport of nutrients into the cell and export of toxic substances outside of the cell

Helps reduce ectopic intra-organ fat

Deficiency may cause cardiovascular disease, neurological disorders, and nonalcoholic fatty liver disease 

Organic unrefined virgin cold-pressed hemp seed oil

Represents <1.5% of the formula to serve as a lubricant. Powders can be very dry and get stuck on the machine which can cause a problem for encapsulation.

100% HPMC hypromellose vegan certified EMBO CAPS® VG ALPHA encapsulation 

NO gelling agents such as carrageenan and pectin. NO preservatives.

Crider, K. S., Yang, T. P., Berry, R. J., & Bailey, L. B. (2012). Folate and DNA methylation: A review of molecular mechanisms and the evidence for folate's role. Advances in Nutrition, 3(1), 21–38. 

Dalto, D., & Matte, J.-J. (2017). Pyridoxine (vitamin B6) and the glutathione peroxidase system; a link between one-carbon metabolism and antioxidation. Nutrients, 9(3), 189. 

DiNicolantonio, J. J., Liu, J., & O'Keefe, J. H. (2018). Thiamine and cardiovascular disease: A literature review. Progress in Cardiovascular Diseases, 61(1), 27–32. 

George, L. (2002). Plasma folate levels and risk of spontaneous abortion. JAMA, 288(15), 1867. 

Han, D., Huang, M., Wang, T., Li, Z., Chen, Y., Liu, C., Lei, Z., & Chu, X. (2019). Lysine methylation of transcription factors in cancer. Cell Death & Disease, 10(4). 

Hanin, I. (1989). pp 180-181. In Lecithin: Technological, biological, and therapeutic aspects. essay, Plenum Pr. 

High-dose niacin is a promising treatment for non-alcoholic fatty liver disease. (2021). Research Features, (134). 

Hübner, U., Alwan, A., Jouma, M., Tabbaa, M., Schorr, H., & Herrmann, W. (2008). Low serum vitamin B12 is associated with recurrent pregnancy loss in Syrian women. Clinical Chemistry and Laboratory Medicine, 46(9). 

Kahrilas, P. (2017). Faculty opinions recommendation of association between vitamin B12 deficiency and long-term use of acid-lowering agents: A systematic review and meta-analysis. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature. 

Kwak, H.-K., Hansen, C. M., Leklem, J. E., Hardin, K., & Shultz, T. D. (2002). Improved vitamin B-6 status is positively related to lymphocyte proliferation in young women consuming a controlled diet. The Journal of Nutrition, 132(11), 3308–3313. 

Lonsdale, D. (2006). A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives. Evidence-Based Complementary and Alternative Medicine, 3(1), 49–59. 

Marinou, K. (2017). Long term metformin use association with vitamin B12 deficiency and anemia. Journal of Diabetes, Metabolic Disorders & Control, 4(1). 

McArthur, J., Tang, H. M., Petocz, P., & Samman, S. (2013). Biological variability and impact of oral contraceptives on vitamins B6, B12 and folate status in women of reproductive age. Nutrients, 5(9), 3634–3645. 

McKenney, J. (2004). New Perspectives on the use of niacin in the treatment of lipid disorders. Archives of Internal Medicine, 164(7), 697. 

Mocellin, S., Briarava, M., & Pilati, P. (2016). Vitamin B6 and Cancer Risk: A Field Synopsis and meta-analysis. Journal of the National Cancer Institute, 109(3). 

Newell-Price, J., Clark, A. J. L., & King, P. (2000). DNA methylation and silencing of gene expression. Trends in Endocrinology & Metabolism, 11(4), 142–148. 

Relation of pantothenic acid to adrenal cortical function. (2009). Nutrition Reviews, 19(3), 79–80. 

Reznikoff-Etiévant, M. F., Zittoun, J., Vaylet, C., Pernet, P., & Milliez, J. (2002). Low vitamin B12 level as a risk factor for very early recurrent abortion. European Journal of Obstetrics & Gynecology and Reproductive Biology, 104(2), 156–159. 

Skalka, H. W., & Prchal, J. T. (1981). Cataracts and riboflavin deficiency. The American Journal of Clinical Nutrition, 34(5), 861–863. 

Suwannasom, N., Kao, I., Pruß, A., Georgieva, R., & Bäumler, H. (2020). Riboflavin: The health benefits of a forgotten natural vitamin. International Journal of Molecular Sciences, 21(3), 950. 

Thiamine (vitamin B1) deficiency. (n.d.). Encyclopedia of Neuroscience, 4067–4067. 

Zeisel, S. (2017). Choline, other methyl-donors and epigenetics. Nutrients, 9(5), 445.

Why Are B Vitamins Essential

B2 (riboflavin), B3, B6, B9 (folate), B12, and choline are required for methylation. Deficiency of these B vitamins and essential nutrient can lead to impairment of the methylation cycle.

What Makes BALANCE Exceptional

Our Bs are in bioavailable forms which increases absorption and utilization especially for individuals who have MTHFR SNPs. Organic shiitake is our natural source of essential choline. There are no fillers; many clean supplement companies add rice hull as a filler. Our hypromellose cellulose capsules are free of carrageenan and pectin. The size 0 capsule is small and vegan certified which may be easier to swallow than larger common size 00. We did not use a heat applied internal sealer such as foam made from polyethylene that can be derived from petrochemicals which can outgas into the product or aluminum foil which can outgas metal toxicity. It is packaged in high-quality glass jars imported from Italy.

What Is Methylation

Methylation occurs by the transferring of a methyl group CH3, a single carbon atom and three hydrogen atoms, via universal methyl donor SAMe (S-adenosylmethionine) that attach to molecules, thereby modifying processes such as detoxification (heavy metals and chemicals), gene expression (DNA/RNA), neurotransmitters, proteins, neurons, cellular membranes, immune cells, enzymes, and hormones.

What Is Bioavailability And Why Does It Matter

Bioavailability is a measure of how much a substance can access circulation for utilization. Bioavailable forms ensures that the body can absorb optimal amounts without requiring a large dose. A substance will only take effect if it can be absorbed so bioavailability is key to delivering benefits. Some people may have genetic impairment such as MTHFR SNP where the body struggles to process folate so a bioavailable form L-5-MTHF that we use can be supportive.

What Are The 6 Conjugation Pathways And How Are B Vitamins Involved

Glutathione conjugation, amino acid conjugation, methylation, sulfation, acetylation, and glucuronidation are the six pathways in phase II detoxification that render toxins less harmful. Phase II detoxification is where most people struggle mainly due to lack of required nutrients. This takes place in the liver and B vitamins are mandatory nutrients required to complete these cycles.